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MORE ABOUT CBD
Looking to learn more about CBD? We've done the research for you and compiled valuable information to assist our consumers in understanding this popular topic. Check out our resources below to learn more.
What is CBD?
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Cannabidiol, or CBD, is one of 104 chemical compounds found in the cannabis plant, Cannabis sativa. https://www.ncbi.nlm.nih.gov/books/NBK425762/
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CBD comes from the male hemp plant and is not psychoactive, which means you won’t get high. CBD supports our body effectively due to our body’s endogenous cannabinoid system. The endocannabinoid system is involved in regulating a variety of functions including sleep, appetite, pain, and immune system response. https://www.ncbi.nlm.nih.gov/pubmed/19675519
Why use CBD?
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CBD is effective in boosting the natural functions of our body’s endogenous cannabinoid system, helping our body regulate itself in many different ways.
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Scientific and clinical studies have shown promise in aiding in the treatment of the following: arthritis, diabetes, alcoholism, MS, chronic pain, schizophrenia, PTSD, depression, antibiotic-resilient infections, epilepsy, and other neurological disorders.
Analgesic
Anti-Bacterial
Anti-Convulsive
Anti-Epileptic
Anti-Proliferative
Anti-Inflammatory
Anti-Spasmodic
Blood Sugar Balancing
Gastrointestinal Relief
Immune Support
Neuroprotective
Sleep Support
Stress/Anxiety Relief
Calming
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Benefits
Pain Relief:
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Marijuana has been used to treat pain as far back as 2900 B.C.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549367/
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Scientific studies have discovered it is CBD that is responsible for pain relief. One study in rats found that CBD injections reduced pain response to surgical incision, while another rat study found that oral CBD treatment significantly reduced sciatic nerve pain and inflammation. https://www.ncbi.nlm.nih.gov/pubmed/17157290
Anxiety and Depression:
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According to the World Health Organization, depression is the single largest contributor to disability worldwide, while anxiety disorders are ranked sixth. https://apps.who.int/iris/bitstream/handle/10665/254610/WHO-MSD-MER-2017.2-eng.pdf;jsessionid=5A8A3844D3FE1340537D86EC8D92883B?sequence=1
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Anxiety and depression are usually treated with pharmaceutical drugs, which can cause several side effects including drowsiness, agitation, insomnia, sexual dysfunction, and headache. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970636/
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Due to all the side effects of pharmaceuticals, and with the early clinical studies showing positive steps, more people are looking to CBD as a more natural approach.
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In one study, 24 people with social anxiety disorder received either 600 mg of CBD or a placebo before a public speaking test. The group that received the CBD had significantly less anxiety, cognitive impairment, and discomfort in their speech performance, compared to the placebo group. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079847/
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CBD has also shown antidepressant-like effects in several animal studies. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823358/
Can Alleviate Cancer-Related Symptoms:
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One study looked at the effects of CBD and THC in 177 people with cancer-related pain who did not experience relief from pain medication. Those treated with an extract containing both compounds experienced a significant reduction in pain compared to those who received only THC extract. https://www.ncbi.nlm.nih.gov/pubmed/19896326
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CBD may also help reduce chemotherapy-induced nausea and vomiting, which are among the most common chemotherapy-related side effects for those with cancer. https://www.ncbi.nlm.nih.gov/pubmed/16983116
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A study showed that CBD inhibited the spread of aggressive breast cancer cells in mice. https://www.ncbi.nlm.nih.gov/pubmed/18025276
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These of course are early studies in animals, so more studies need to be done to understand its full impact on humans.
May Reduce Acne:
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Acne affects 9% of the US population. https://www.ncbi.nlm.nih.gov/pubmed/25597339
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A study concluded that CBD may be an efficient and safe way to treat acne, thanks in part to its remarkable anti-inflammatory qualities. https://www.ncbi.nlm.nih.gov/pubmed/27094344
Neuroprotective Properties:
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CBD is most studied in the area of epilepsy and Multiple Sclerosis.
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A study gave 214 people with severe epilepsy 0.9–2.3 grams of CBD oil per pound (2–5 g/kg) of body weight. Their seizures were reduced by a median of 36.5%. https://www.ncbi.nlm.nih.gov/pubmed/26724101
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A study found that CBD oil significantly reduced seizure activity in children with Dravet syndrome, a complex childhood epilepsy disorder, compared to a placebo. https://www.ncbi.nlm.nih.gov/pubmed/28538134
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Several studies have shown that treatment with CBD improved the quality of life and sleep quality for people with Parkinson’s disease. https://www.ncbi.nlm.nih.gov/pubmed/25237116
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Animal and test-tube studies have shown that CBD may decrease inflammation and help prevent the neurodegeneration associated with Alzheimer’s disease. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289988/
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In one long-term study, researchers gave CBD to mice genetically predisposed to Alzheimer’s disease, finding that it helped prevent cognitive decline. https://www.ncbi.nlm.nih.gov/pubmed/25024347
Heart Health:
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High blood pressure is linked to higher risks of several health conditions, including stroke, heart attack, and metabolic syndrome. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699411/
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Clinical studies are showing that CBD has a positive effect on high blood pressure.
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One recent study treated 10 healthy men with one dose of 600 mg of CBD oil and found it reduced resting blood pressure, compared to a placebo. The same study also gave the men stress tests that normally increase blood pressure. Interestingly, the single dose of CBD led the men to experience a smaller blood pressure increase than normal in response to these tests. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470879/
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A study found that treatment with CBD reduced oxidative stress and prevented heart damage in diabetic mice with heart disease. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026637/
Sleep:
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According to the National Sleep Foundation, 50 to 70 million U.S. adults experience symptoms of a sleep disorder. About 30 to 40 percent of the population will experience insomnia at some point in their lives, and about 10 to 15 percent of adults will deal with chronic insomnia. https://www.sleepfoundation.org/articles/sleep-studies
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A seemingly inactive state of sleep is a dynamic and critical process that helps us store memories, build immunity, repair tissue, regulate metabolism and blood pressure, control appetite and blood sugar, and process learning, along with a myriad of other physiological processes – all of which are regulated by the endocannabinoid system. https://www.projectcbd.org/medicine/cannabis-sleep-disturbances
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Sir William B. O’Shaughnessy in 1843 led to studies that underscored the remedial properties of “Indian hemp” for sleep disorders.
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Of all anesthetics ever proposed, Indian hemp is the one that produced a narcotism most closely resembling natural sleep without causing any extraordinary excitement of the vessels, any particular suspension of secretions, or without fear of a dangerous reaction. https://www.projectcbd.org/medicine/cannabis-sleep-disturbances
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Preliminary studies are finding that CBD has treatment for insomnia. CBD may hold promise for REM sleep behavior disorder and excessive daytime sleepiness. https://www.ncbi.nlm.nih.gov/pubmed/28349316
Other Possible Benefits:
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Although more clinical studies are needed, there are early ideas that CBD can help in the following areas.
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Antipsychotic effects: Studies suggest that CBD may help people with schizophrenia and other mental disorders by reducing psychotic symptoms. https://www.ncbi.nlm.nih.gov/pubmed/25667194
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Substance abuse treatment: CBD has been shown to modify circuits in the brain related to drug addiction. In rats, CBD has been shown to reduce morphine dependence and heroin-seeking behavior. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444130/
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Anti-tumor effects: In test-tube and animal studies, CBD has demonstrated anti-tumor effects. In animals, it has been shown to prevent the spread of breast, prostate, brain, colon, and lung cancer. https://www.ncbi.nlm.nih.gov/pubmed/25916739
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Diabetes prevention: In diabetic mice, treatment with CBD reduced the incidence of diabetes by 56% and significantly reduced inflammation. https://www.ncbi.nlm.nih.gov/pubmed/16698671
Things to consider when choosing what CBD product is best for you
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CBD is being produced without any regulation, resulting in products that vary widely in quality, said Marcel Bonn-Miller, an adjunct assistant professor of psychology in psychiatry at the University of Pennsylvania School of Medicine.
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Meanwhile, a 2017 study led by Bonn-Miller found that nearly 7 of 10 CBD products didn't contain the amount of marijuana extract promised on the label.
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Nearly 43 percent of the products contained too little CBD, while about 26 percent contained too much, Bonn-Miller said.
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About 1 in 5 CBD products contained the intoxicating pot chemical THC, Bonn-Miller and his colleagues found. https://www.webmd.com/pain-management/news/20180507/cbd-oil-all-the-rage-but-is-it-safe-effective#1
Things to consider if you are taking medication
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When taking CBD orally, it is metabolized through the liver, and the main enzymes to metabolize CBD are Cytochrome P450-complex enzymes. These enzymes are responsible for also metabolizing around 60% of pharmaceutical drugs.
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CBD monopolizes the metabolism process, which will interfere with pharmaceutical drugs. There are negatives and positives to this interaction…but one should consult a medical professional before using CBD.
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Some medications that will be interfered with are macrolides, calcium channel blockers, benzodiazepines, cyclosporine, sildenafil, anticonvulsants, antihistamines, haloperidol, antiretrovirals, some statins, many antidepressants, opioids, antipsychotics, and beta blockers. https://www.solcbd.com/blogs/news/118305477-what-pharmaceutical-drugs-can-interfere-with-cbd
Things to consider - side effects
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More than 20,000 studies have been done in the past 15 years on cannabis, hemp, and cannabinoids, and the results have been overwhelmingly supportive of the therapeutic potential and viability of CBD oil. Still, it is important to know that there are potential side effects and cautions before using CBD.
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Possible side effects of using CBD oil, such as fatigue, dry mouth, lightheadedness, hypotension, and impaired motor functions…but this is more in high dosages and not in moderate therapeutic amounts. https://www.organicfacts.net/health-benefits/oils/cbd-oil-benefits-uses-side-effects.html
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Considering the long list of side effects in the most common pharmaceuticals being prescribed, CBD as a standalone treatment seems to be a much healthier alternative to that of a manufactured drug. https://cbdeducationonline.com/what-are-the-side-effects-of-cbd-oil-in-humans/
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Blood Pressure: One of the notable soothing benefits of CBD oil is its effect on blood pressure, helping protect heart health and promote calmness in the body. However, if you are already taking medication for hypertension, combining this with CBD oil can potentially cause dangerously low blood pressure (hypotension). https://www.organicfacts.net/health-benefits/oils/cbd-oil-benefits-uses-side-effects.html
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CBD and Pets - what gives?
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CBD can help pets in many different aspects - reduces anxiety, depression, seizures, and epilepsy, relieves pain, aids with bowel disease, reduces inflammation, protects the nervous system, and can improve appetite.
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Reducing Anxiety
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Pets can suffer from separation anxiety and noise anxiety, and CBD has been extensively studied in the area of anxiety. CBD has been shown to aid in the areas of anxiety with travel (car rides of any distance), thunderstorms, having company over, and fireworks.
https://www.consumerhealthdigest.com/cbd-for-pets/cbd-oil-for-anxiety-in-dogs.html
Seizures and Epilepsy
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Estimates suggest that up to 5% of dogs suffer from seizures. Most dogs with seizures are given drugs such as phenobarbital and potassium bromide. Sure, these drugs may help control the seizures. But they can be extremely harmful to your dog’s liver and other organs. https://www.dogsnaturallymagazine.com/cbd-oil-for-dogs/
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In one study, 7 of 8 patients with drug-resistant epilepsy saw a definite improvement within 4 to 5 months. https://www.ncbi.nlm.nih.gov/pubmed/7028792
Relieving Pain
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CBD can mitigate pain issues with your pet, especially when your pet is growing old. CBD helps with neuropathy nerve pain, and inflammation on oxidative stress which leads to degeneration and premature aging.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371734/
https://www.ncbi.nlm.nih.gov/pubmed/21238581
Aids with Bowel Disease
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Animal studies show that CBD can prevent colitis and mobility in inflamed bowels. https://www.ncbi.nlm.nih.gov/pubmed/19442536
Help With Neurodegenerative Diseases
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For senior dogs, CBD can protect the brain from cell death caused by free radicals and toxins.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC20965/
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